The recent release of Joomla 3.9.16 includes the addition of a database index to the users table. If your Joomla website happens to have duplicate usernames, this index addition will fail and you will see an error as in the attached image. The rest of the update will typically suceed just fine.
Should you have this error, you must first find and solve the duplicate username problems. Each username in your site should be unique, so you should either rename or remove duplicates.